摘要
严重急性呼吸系统综合征(SARS)是由SARS冠状病毒(SARS-CoV)引起的一种新型人类疾病,具有高致病性、高传染性、高死亡率的特点。Spike蛋白是冠状病毒膜表面的糖蛋白突出,构成病毒的包膜子粒,在病毒与其受体结合、通过膜融合进入宿主细胞以及诱导机体产生中和性抗体的过程中发挥着重要的作用。目前利用Spike蛋白开发出的一些防治SARS的药物和疫苗在动物和体外实验中有良好的抗病毒作用。本文阐述了SARS-CoVSpike蛋白的结构与功能,为抗SARS药物及疫苗的研发提供一定的理论基础。
Severe acute respiratory syndrome （SARS） which is caused by a novel coronavirus SARS-CoV, is characterized as a disease of high mortality and epidemic. Spike protein of SARS-CoV form the characteristic corona of large, distinctive spikes in the virus envelope, which initiate entry of coronavirus by binding to cell surface receptors followed by conformational changes leading to membrane fusion and delivery of the genome in the cytoplasm. They are also major targets of neutralizing antibodies. Vaccine or medicines based on Spike protein which block binding to cell receptors or inhibit receptor-induced conformational change in Spike protein might block SARS infection.
出处
《生物技术通讯》
CAS
2005年第5期541-544,共4页
Letters in Biotechnology
