摘要
检测２１例糖尿病合并冠心病患者和３６例单纯冠心病患者及３０名健康人红细胞超氧化物歧化酶（ＲＢＣ－ＳＯＤ）活性、血清丙二醛（ＭＤＡ），血浆血栓素Ｂ２（ＴＸＢ２）、６－酮－前列环素Ｆ１α（６－ｋｅｔｏ－ＰＧＦ１α）等指标的变化及其相互关系，并观察临床中医辨证分型的特点。结果表明：两组患者的体重指数（ＢＭＩ）、ＭＤＡ、ＴＸＢ２、胆固醇（ＴＣ）、甘油三酯（ＴＧ）均比健康人高（Ｐ＜０．０５～０．００１）；ＲＢＣ－ＳＯＤ、６－ｋｅｔｏ－ＰＧＦ１α均比健康人低（Ｐ＜０．０１～０．００１）。两患者组间ＲＢＣ－ＳＯＤ、ＴＸＢ２、空腹血糖（ＦＢＧ）有显著性差别（Ｐ＜０．０１）。ＭＤＡ与ＴＸＢ２、ＴＧ、ＦＢＧ、ＢＭＩ呈正相关，与６－ｋｅｔｏ－ＰＧＦ１α呈负相关，ＳＯＤ和ＴＣ、舒张压呈负相关；多因素逐步判别分析表明：舒张压对因变量影响最大，其次是血糖、６－ｋｅｔｏ－ＰＧＦ１α、ＴＸＢ２、ＳＯＤ。糖尿病合并冠心病患者以气阴两虚血瘀为主要证型，单纯冠心病患者以气虚血瘀为主要证型。
Activity of erythrocyte superoxide dismutase (RBC-SOD), levels of serum malondialdehyde (MDA), plasma 6-keto-prostaglandin F 1 α (6-keto-PGF 1 α)and thromboxane B 2(TXB 2)were measured in 30 healthy subjects and 57 coronary heart desease(CHD) patients inoluding 21 cases complicated with diabetes and 36 without. Their characteristics of Syndrome Differentiation and taping were observed. The results showed that the activity of RBC-SOD, 6-keto-PGF 1 a in CHD patients were significantly lower than those in the healthy subjects, but the levels of TXB 2,MDA were significantly higher. The levels of TXB 2 in CHD patients with diabetes were significantly higher than those without, but the activity of RBC-SOD were significantly lower. There were remarkably positive correlations between the levels of serum MDA and that of blood sugar, TXB 2,TG and BMI in CHD patients with diabetes.There were remarkably negative correlations between the levels of serum MDA and plasma 6-keto-PGF 1 α. The results suggested that the metabolic abnormality of lipoperoxides was more serious in CHD patients with diabetes than without.The main Syndrome of CHD with diabetes was Qi-yin Deficiency with Blood Stasis, while that of without diabetes was Qi Deficiency with Blood Stasis.
出处
《中国中西医结合杂志》
CAS
CSCD
北大核心
1996年第1期29-31,共3页
Chinese Journal of Integrated Traditional and Western Medicine
关键词
糖尿病
冠心病
辩证分型
血栓素B2
脂质过氧化
coronary heart disease complicated with diabetes, Syndrome Differentiation-typing, thromboxane B_2, superoxide dismutase
