摘要
目的评价替硝唑与甲硝唑治疗幽门螺旋杆菌的疗效、不良反应及成本-效果。方法将80例幽门螺旋杆菌患者随机分成2组,分别口服替硝唑(实验组)和甲硝唑(对照组),对替硝唑与甲硝唑治疗幽门螺旋杆菌的疗效、不良反应并运用药物经济学成本-效果分析法进行评价。结果替硝唑与甲硝唑治疗幽门螺旋杆菌的总有效率基本相同,分别为97.5%和92.5%(P>0·05);不良反应发生率分别为5%和22.5%(P<0.01);成本-效果比分别为1.48和0.92(P<0.01)。结论替硝唑与甲硝唑均能有效治疗幽门螺旋杆菌。甲硝唑成本-效果比优于替硝唑。但其不良反应发生率高于替硝唑。
Aim To estimate the curative effect, adverse reaction and cost - effectiveness of tinidazole and metronidazole for tretment of helicobacler pylort. Methods 80 patients with helicobacler pylort were randomly divided into groups for treatment with oral tinidazole （the treatment group）or oral metronidazole （hte concrol group） respectively. Their curative effects and the adverse reactions were observed, meanwhile both cost - effectiveness of them were evaluated by pharmacoeconomics. Results The effective ratios were 97.5 % and 92.5% （P 〉0.05 ）for helicobacler pylort. The ratio of the adverse reaction was 5% for tinidazole and 22.5% for metronidazole （P 〈 0.01 ）. The cost - effectiveness ratio of tinidazole was 1.48 and 0.92 for metronidazole （ P 〈 0.01 ）. Conclusion Both of tinidazole and metronidazole can tret the Helicobacler pylort effectively. The cost - effectiveness ratio of metronidazole is lower than that of tinidazole. But the adverse reaction ratio of metronidazole is Higher than that of tinidazole.
出处
《安徽医药》
CAS
2005年第10期781-782,共2页
Anhui Medical and Pharmaceutical Journal
