摘要
目的：研究慢性阻塞性肺病（ＣＯＰＤ）患者合用硝苯地平前后茶碱稳态血药浓度及药物动力学的变化。方法：高效液相色谱（ＨＰＬＣ）法测定９名ＣＯＰＤ患者ｐｏ氨茶碱片（２００ｍｇ，ｔｉｄ）５ｄ后及加服硝苯地平（１０ｍｇ，ｔｉｄ）５ｄ后茶碱血药浓度，以ＰＫＢＰ－Ｎ＿１计算机程序拟合药物动力学参数。结果：ＣＯＰＤ患者合用硝苯地平５ｄ后，茶碱稳态平均血药浓度下降１．７７±２．０４ｍｇ／Ｌ，ｃ＿（ｍａｘ）和ＡＵＣ＿（０～８）均较用硝苯地平前降低，分别为１２．３±６．５和９．９±４．９ｍｇ／Ｌ，８２．４±５２．１和６２．５±３８．８（ｍｇ·ｈ）／Ｌ（Ｐ＜０．０５）。其它药物动力学参数无明显改变（Ｐ＞０．０５）。结论：ＣＯＰＤ患者合并使用硝苯地平，无需改变氨茶碱的治疗剂量，两药可以合用。
OBJECTIVE:To investigate the effect of nifedipine on serum concentrations at steady state and itspharmacokinetics of theophylline. METHOD :Serum theophylline concentrations in 9 patients with chronic obstruc- tive pulmonary diseases (COPD) were determined with high pressure liquid chromatography (HPLC).The calcula- tion of pharmacokinetic parameters was based on an one-compartment model using a PKBp-N1 computerized pro- gram. RESULT:After administration of nifedipine for 5 days, the mean serum theophylline concentration atsteady-state was decreased by 1. 77±2. 04 mg/L. cmax and AUC0～8 was lower than those obtained before nifedipine. They were 12. 3±6. 3 and 9. 9±4.9mg/L, 82. 4±52. 1 and 62.5±38.8(mg·h)/L, respectively(P<0. 05).Butthere was no signifcant variation in modification of other pharmacokinetic parameters. CONCLUSION :It is not nec- essary to change the therapeutic dose of aminophylline when the drug is taken in combination with nifedipine inCOPD patients.
出处
《中国药学杂志》
CAS
CSCD
北大核心
1996年第4期222-225,共4页
Chinese Pharmaceutical Journal
基金
河北省卫生厅资助课题
关键词
茶碱
硝苯地平
药物动力学
阻塞性肺疾病
theophylline ,nifedipine,interaction,pharmacokinetics , HPLC
