摘要
用雄性Wistar大鼠,采用Feeney等的落体撞击法造成左顶颅脑挫伤。动物随机分组,给于TRH类似物YM14673(0.1mg·kg-1或1.0mg.kg-1,ip)或等体积生理盐水。治疗组可明显地减轻脑水肿。
The effect of TRH analogne,YM 14673:Nα-[[(S)-4-oxo-2-azetidinyl]-earbenyl)-L-histidyl-L-prolinamide] dihydrate,on traumatic brain edema were studied in maleWistar rats,The cerebral contusion was produced by Feeney's dropping weight methed. Animals wererandomly divided into 4 groups:normal group and YM14673(0.1 mg·kg-1,ip), YM14673(1.0mg· kg-1,ip)and a control group(given equal volume of physiological saline,ip)after cerebralcoutusion. Contents of water in brain tissue were measured.These results suggest that treatments withYM14673 significantly reduced brain edema than control group(P<0.05).
出处
《药学学报》
CAS
CSCD
北大核心
1996年第4期250-253,共4页
Acta Pharmaceutica Sinica
关键词
TRH
促甲状腺素
类似物
YM14673
脑损伤
脑水肿
Brain contusion
rain edema
Thyrotropin-releasing hormone(TRH)
Thyrotropin-releasing hormone analogue(YM14673)