摘要
目的:探讨中药促动胶囊对全身炎症反应综合征(S IRS)患者肠屏障的保护作用及其机制。方法:将临床符合S IRS诊断标准的78例患者随机分为促动胶囊全方(主要由厚朴、枳实、黄芪、大黄等组成)组、大黄组、理气组、益气活血组和普瑞博思组。用鲎试剂法测定血浆内毒素含量;用高压气相色谱法测定尿乳果糖/甘露醇比值(L/M),以反映肠黏膜通透性;观察患者入院第1 d及第7 d时有关指标的变化情况并进行胃肠功能评分。结果:与普瑞博思组相比,促动胶囊除能改善S IRS患者肠鸣音外,还可使增加的尿L/M降低,改善肠黏膜通透性,改善胃肠功能评分,并可明显减轻内毒素血症。结论:中药复方促动胶囊可多靶位保护S IRS患者肠屏障功能。
Objective： To observe the protective effects and its mechanism of traditional Chinese medicine Cudong capsule （促动胶囊） on intestinal barrier in patients with SIRS. Methods： Seventy-eight patients with systemic inflammatory response syndrome （SIRS） were randomly divided into five groups.. Cudong capsule group （group A）, rhubarb group （group B）, Qi- regulating （理气） group （group C）, supplement Qi and activating blood circulation group （group D）, the cisapride group （group E）. Plasma endotoxin concentration was detected with limulus test, lactulose/mannitol ratio （L/M） was measured with gas chromatography to reflect the gut permeability. The relative indexes were measured on the first and 7 th day after admission and the gut -intestine function score was performed. Results： Compared with group E, Cudong capsule could decrease the L/M, therefore improved gut permeability and gut -intestine score, and alleviated the endotoxemia. Conclusion： Traditional Chinese medicine Cudong capsule may protect the intestinal barrier function in SIRS patients.
出处
《中国中西医结合急救杂志》
CAS
2005年第5期259-262,共4页
Chinese Journal of Integrated Traditional and Western Medicine in Intensive and Critical Care
基金
北京市中医局资助课题(9810144)
关键词
促动胶囊
全身炎症反应综合征
肠屏障
中药
Cudong capsule
systemic inflammatory response syndrome
intestinal barrier
traditional Chinese medicine
