摘要
多细胞生物中存在细胞竞争的行为早在1888年就已经提出,但直到1975年才被实验首次证实。最近对果蝇进行的遗传分析,揭示了调节细胞竞争行为的基因网络,并提出了程序性细胞竞争作为群体水平的细胞选择机制。细胞竞争对早期肿瘤形成的促进作用和对干细胞自我更新的重大意义,可为今后对器官功能退化、衰老及肿瘤的治疗和干细胞替代疗法的改进提供全新的实践模型。
It was proposed as early as in 1888 that cells of multi-cellular organisms may compete with one another, but it was not experimentally confirmed until 1975. A recent genetic analysis of drosophila reveals a gene network that controls cell competition, and proposes that programmed cell competition act as a cell selection mechanism at the population level. If the genes regulating cellular competitiveness in drosophila have a conserved function in mammals, the study of cell competition can have an impact on several biomedical fields, including functional degeneration, cancer, or stem cell therapies.
出处
《浙江树人大学学报》
2005年第5期114-116,共3页
Journal of Zhejiang Shuren University
