摘要
目的:探讨进展期结直肠癌经淋巴结转移规律,指导手术清扫范围,以期提高根治效果.方法:回顾性分析了124例进展期结直肠癌的住院资料、术后切除标本的淋巴结解剖数目以及病理检查结果,按照性别、年龄、肿瘤直径、解剖部位、分化程度以及临床病理分期进行统计学比较,分析淋巴结转移规律的相关因素.结果:结直肠癌经淋巴结转移与肿瘤的部位、浸润深度及分化程度明显相关.直肠癌淋巴结转移高于结肠癌,T3～T4结直肠癌的淋巴结转移率及转移度显著高于T1～T2(P＜0.05),低分化肿瘤的淋巴结转移率和转移度高于高分化肿瘤(P＜0.05).性别、年龄以及肿瘤的肠腔内直径不是结直肠癌经淋巴结转移的相关因素.结论:肿瘤浸润肠壁的深度、细胞分化程度及癌灶的部位是结直肠癌经淋巴结转移的好发因素.手术应根据淋巴结转移规律合理地廓清淋巴结,对于直肠癌肿、T3期或无远处转移的T4期、术前结肠镜检查发现同时有2个或以上瘤灶、术前病理报告为未分化腺癌的病例,相应的结直肠系膜切除更应该彻底,以尽大可能地去除转移的淋巴结和潜在的微转移灶.
Objective：To explore correlation factor of lymphatic metastasis of advanced colorectal cancer in order to guide the excision extent and improve the effect of radical excision. Methods： Clinicopathologic data of 124 cases of advanced colorectal cancers were analyzed retrospectively. Results： The lymphatic metastasis of advanced colorectal cancer had obvious relationship with tumor site, differentiation degree and clinicopathological stage. Lymphatic metastasis was more common in rectal cancer than in colon cancer. The lymphatic metastasis rate in T3-T4 stage colorectal cancer was higher than that in T1-T2 stage, and so was in poorly differentiated colorectal cancer than that in well differentiated. The gender, age and diameter of tumor were not correlation factor of lymphatic metastasis. Conclusion：Lymphatic metastasis of advanced colorectal cancer is associated with depth of invasion, differentiation and tumor site. It is essential to clean up lymph node according to the metastasis regularity.
出处
《大肠肛门病外科杂志》
2005年第3期182-184,共3页
Journal of Coloproctological Surgery
关键词
结肠癌
直肠癌
淋巴结
转移
Colorectal carcinoma
Lymph Node
Metastasis
