摘要
目的:观察血清基质金属蛋白酶3(MMP-3)与基质金属蛋白酶9(MMP-9)在脑梗死患者不同时期的动态变化,探讨其临床意义。方法:62例脑梗死和腔隙性脑梗死患者分别分为观察组1和2,30例健康体检者为对照组,分别检测观察组发病2-5 d、15 d及对照组的血清MMP-3、MMP-9的含量及神经功能缺损程度评分(CNFDS)。结果:血清MMP-9和MMP-3水平发病2-5 d时,观察组1、2与对照组比较均显著升高(P<0.01),观察组1 MMP-9水平比观察组2升高更显著(P<0.01);发病15 d时,观察组1、2 MMP-9和MMP-3水平与对照组比较差异无显著性意义。发病2-5 d的血清MMP-9和MMP-3水平与预后呈负相关。结论:脑梗死发病早期血清MMP-9与MMP-3水平的高低与临床病程有关,而且是判断脑梗死近期预后的重要指标。
Objective： To investigate the dynamic changes and clinical significance of serum matrix metalloproteinase-3 （MMP-3） and matrix metalloproteinase-9 （MMP-9） on various stages in patients with cerebral infarction. Methods： 62 cerebral infarction and lacunar infarction patients were divided into the observation group one and the observation group two, while 30 healthy people served as the control group. Serum MMP-3 and MMP-9 levels and the scores of the Clinical Neurological Function Deficient （CNFDS） were measured during the onset 2 to 5 days and 15 days in the observation group and the control group. Results： The levels of serum MMP-9 and MMP-3 during 2 to 5 days of the cerebral infarction were higher than those in the control group （P〈0.01）. The serum MMP- 9 levels in the observation group one were significantly higher than those in the observation group two （P^0.01）. The levels of serum MMP-3 and MMP-9 at the onset 15 days of the observation groups had no significant difference compared with those of the control group. Correlation analysis showed that there was a negative correlation between MMP-9, MMP-3 and prognosis. Conclusion： MMP-3 and MMP-9 may contribute to the pathologic course in the early stage of cerebral infarction. The levels of MMP-3 and MMP-9 are correlated with the clinical course of the disease and prognosis.
出处
《中国康复》
2005年第5期278-280,共3页
Chinese Journal of Rehabilitation
关键词
脑梗死
基质金属蛋白酶3
基质金属蛋白酶9
cerebral infarction
matrix metalloproteinase-3
matrix metalloproteinase-9
