摘要
目的探讨青年人和老年人大肠癌的临床及病理特征。方法对78例青年人和老年人大肠癌的临床特征进行分析,测定患者血清CEA、CA242,采用免疫组化方法测定p53、c鄄erbB鄄2和CD44v6蛋白的表达情况。结果青年组和老年组大肠癌在性别分布上无差异,发病部位无差异,青年组肿瘤细胞多数分化程度差(低鄄未分化),老年组肿瘤细胞分化程度较好(高鄄中分化,P<0.05),P<0.05;青年组病程较晚(Duke蒺sC+D),病例的比例较老年组高(P<0.05);青年组和老年组CEA、CA242、p53、c鄄erbB鄄2、CD44v6的阳性率分别为34.1%、56.1%、53.7%、56.1%、36.6%、和19.6%、23.2%、33.9%、37.5%、17.9%,除CEA外,其余4项指标,2组比较均有显著性差异(P<0.05)。结论青年人和老年人大肠癌有不同的临床特点及生物学特征。
Objective To study the clinical and pathological characteristics of patients with colorectal carcinoma. Methods From September 1999 to September young and old 2004 clinical characteristics of 22 young and 56 old patients with colorectal carcinoma were analyzed retrospectively. Serum CEA and CA 242 levels were measured, p53 c-erbB-2 and CD44v6 protein were detected by immunohistochemical methods in all patients.Results No significant difference was found in sex and site of colorectal carcinoma between young and old patients.The rates of poor-differentiated group and advanced stage （Duke＇s C＋D） in young patients were higher than those in old patients （P 〈 0.05）.The positive rate of CEA,CA242, p53,c-erbB-2,CD44v6 in young and old patients were 34.1%,56.1%, 53.7%, 65.1%, 36.6% and 19.6%, 23.2%, 33.9%, 37.5%, 17.9% respectively.There were significant difference between young and old one in four items except CEA（P 〈 0.05）. Conclusion There are different clinical characteristics and biological behaviors between young and old patients with colorectal carcinoma.
出处
《岭南现代临床外科》
2005年第3期186-187,196,共3页
Lingnan Modern Clinics in Surgery
