摘要
目的分析3种方案对胰岛素抵抗多囊卵巢综合征(PCOS)患者的促排卵结局,探讨二甲双胍对胰岛素抵抗PCOS患者的应用价值及其作用机制。方法将100例胰岛素抵抗PCOS患者随机分为A,B,C3组。A组34例用Diane-35治疗3个周期后用CC+HMG促排卵;B组35例用二甲双胍治疗3个月后用CC+HMG促排卵;C组31倒应用Diane-35加二甲双胍治疗3个月后用CC+HMG促排卵。观察3组病人治疗前后的BMI,T,FINS,TNF-α及排卵率。结果3组病人治行后BMI及T差异无显著性(P>0.05);A组较B,C两组FINS,TNF-α及排卵率差异有显著性(P<0.05)。结论胰岛素抵抗PCOS患者治疗的关键在于应用胰岛素增敏剂降低FINS,Diane-35虽可降低血T,但促排卵结局并不理想。
Objective To analyze the effects of the three ovulation progrants on the treatment of insulin-resisting （IR）patients with polycystic ovary syndrome （PCOS）,and investigate kthe applicable value and the reason of impact of metformin as well.Methods One hundred insulin-resisting cases with PCOS were divided into therr groups randomly.Patients in group A（n=34）were given Diane-35 for three eycles and then were given Clomiphene citrate （CC）plus HMG.Group B（n=35） were given metformin for three mouths and then were given CCplus HMG.Group C（n=31） were treated with Diane-35 and metformin for three months and then were treated with CC and HMG.The BMI,T,FINS,TNF-αand ovulation rate of the patients in the three groups were observed and studied before and after treatment .Results There was no obvious difference in the aspects of BMI and testosterone （T） after treatment in the three groups （P〉0.05）;Whereas the FINS,TNF-αand the ovulation rate in group A were significant different （P〈0.05）from those in group B and C.Conclusion The key of the treatment for the IR patients with PCOS is to use the drug which can increase the sensitivity of insulin to decrease the FINS Diane-35 can reduce the level of T,but the effects of ovulation rate are not satisfied.
出处
《潍坊医学院学报》
2005年第5期321-323,共3页
Acta Academiae Medicinae Weifang
