摘要
目的比较丙酸氟替卡松在哮喘控制良好的轻到中度哮喘儿童中qd与bid吸入治疗的疗效.方法选择77例哮喘控制良好的患儿,随机分为两组,分别给予100μg丙酸氟替卡松qd和bid吸入8周后,评价晨间PEF等指标,通过方差分析比较两组差异.结果两组1～8、1～6、7～8周晨间PEF均在95%的可信区间,证明bid与qd吸入丙酸氟替卡松的疗效在本组实验设计中无差异.无论是qd还是bid吸入,对轻到中度哮喘患儿症状的控制均让人满意.结论对于控制良好的轻到中度哮喘患儿,丙酸氟替卡松100 μg晚上一次性吸入与50 μg早晚各吸入一次的效果均确切,且没有差别.
Objective To compare the clinical effect of once-daily treatment of fluticasone propionate with twice-daily treatment in children with as mild-to-moderate asthma. Methods Seventy-seven cases of children with well-controlled asthma were randomized into two groups： one group with once-daily treatment of fluticasone propionate, the other with twice-daily treatment. After eight weeks of treatment, PEF was avaluated, and analyzed with covariance analysis to confirm relevance. Results All the week am 1-8, 1-6 and 7-8 PEF were well within the 95% CI, and thus demonstrated the clinical equivalence between bid and qd administration. Both methods were ideal for treatment of children with mild-to-moderate asthma. Conclusion Once-daily dosing with fluticasone propionate （100μg） shows clinical equivalence to twice-daily therapy （50 μg twice daily） for maintenance therapy of children with well controlled mild-to-moderate asthma.
出处
《福建医药杂志》
CAS
2005年第5期10-12,共3页
Fujian Medical Journal
关键词
丙酸氟替卡松
儿童哮喘
Fluticasone propionate
Children asthma
