摘要
过去认为外周感觉神经末梢和免疫系统是两个不相关的系统,现已证明免疫系统和外周感觉神经末梢是有相互作用的,外周的传入神经末梢能产生内在的疼痛调节。免疫细胞释放的阿片肽和位于外周炎症组织的阿片受体的相互作用可导致内源性镇痛。从免疫细胞产生和释放的阿片样物质的作用可能是产生外周疼痛的一种未经发现的途径。
The nervous system and immune system communicate with each other by the action of cytokines and neuropeptides. Interactions between immune cell-derived opioid peptides and opioid receptors located in peripheral inflamed tissue lead to endogenous analgesia. The activation of opioid production and release from immune cells may be a novel approach to the development of peripherally acting analgesics. Because such drugs would be targeted towards peripheral injured tissue, these analgesics should lack unwanted central side effects typically associated with opioids.
出处
《实用疼痛学杂志》
2005年第4期241-244,共4页
Pain Clinic Journal
