摘要
在开展国家863计划“通塞脉微丸的研究与开发”等多项课题研究基础上,结合名优中成药特点,从拆方研究、药效物质基础的提取分离方法、效应物质基础的确认、效应物质基础的成分分离解析及确定、指纹图谱谱效相关性、效应物质体内过程的构成变化及其作用靶点、复方多环节、多靶点整合调节机制以及重组现代化复方中药的系统研究等方面探讨了名优中成药二次开发研究的思路与方法,对当前名优中成药二次开发研究具有一定的指导作用。
On the basis of the study of a given subject of the project 'the Research and Development of Tongsaimai Pills' of the 863 Program and in combination with the characteristics of Chinese patent drugs this article investigates the study thought and method of the secondary development of Chinese patent drugs with brand name and high quality from the following aspects: the study of prescription dismantlement; the method for the extraction and separation of effective material fundamentals of drugs, the identification of effective material fundamentals; the separation, analysis and i-dentification of the components of effective material fundamentals; the correlationship between fingerprints and their results, the change in the constitution of process in vivo of effective materials and their target, the integrate and coordi-native mechanisms of the multi - link and multi - target of compound prescriptions; and the study on the recombination of the system of compound prescriptions of modern Chinese medicine. It may have a given guiding role in the study of the seconday development of Chinese patent drugs with brand name and high quality at present.
出处
《世界科学技术-中医药现代化》
2005年第4期49-53,27,共6页
Modernization of Traditional Chinese Medicine and Materia Medica-World Science and Technology
基金
国家863计划"创新药物与中药现代化"重大专项课题(2003AA2Z3247)通塞脉微丸的研究与开发江苏省自然基金项目 (BK2005150)通塞脉微丸有效部位群指纹图谱谱效相关性研究
江苏省科技厅"十五"重大科技攻关项目(BK2001209)通塞脉片复方活性部位群及其药效学研究课题
