摘要
为观察孕期鼠使用二氢埃托啡（ＤＨＥ）对仔鼠神经行为致畸的影响，比较了皮下注射，高（５０μｇ·ｋｇ－１）、中（０．５μｇ·ｋｇ－１）、低（０．０５μｇ·ｋｇ－１）剂量ＤＨＥ和等量生理盐水小鼠所生仔鼠神经行为致畸的各项指标。结果提示ＤＨＥ对仔鼠神经行为致畸的各项指标有不同程度的影响，差异有显著性。
High level (50 μg· kg-1), middle level (0. 5μg·kg-1) and low level(0.05 μg· kg-1) of dihydroetorphine (DHE) were subcutaneously injected in three groupsof mice respectively. Indexes of neurobehavioral teratology were studied. The resultssuggested that some effects of DHE on body weight, physiologic landmarks, reflexesdevelopment and sensory function, movement coordination, learning and memory andlocomotor activity in offsprings were found.
