摘要
目的探讨肾透明细胞肉瘤(c lear cell sarcom a of the k idney,CCSK)的临床病理特点、免疫表型特征及鉴别诊断。方法应用HE和免疫组化vim entin、bc l-2、desm in、S-100蛋白、CD99、CD34、CD117、CK、EMA染色,观察2例CCSK的病理组织学形态,并复习文献。结果镜下见瘤细胞为上皮样或短梭形,被分枝状纤维血管间质分隔成巢团状,部分区域见黏液样变性微囊肿和细胞外胶原玻璃样变类似骨样组织的硬化型等形态变异。免疫组化示:瘤细胞vim entin和bc l-2弥漫阳性,余为阴性。结论CCSK是一种罕见的儿童期恶性肾肿瘤,诊断主要依靠组织病理学和免疫组化,熟悉其形态学变异有利于与其它类似病变如肾母细胞瘤、先天性中胚叶肾瘤、肾恶性横纹肌样瘤、原始神经外胚叶肿瘤等鉴别。
Purpose To study the clinicopathological and immunohistochemical features, and differential diagnosis of clear cell sarcoma of kidney （CCSK）. Methods Two cases of CCSK were investigated by means of light microscopy, HE stain, immunohisto-chemical stain for vimentin, bcl-2, desmin, S-100 protein, CD99, CD34, CD117, CK and EMA, together with review of the related liter-ature. Results Microscopically, the tumor cells were epithelioid or short spindled and special nests of tumor cells separated by arboring fibrovascular septa. Such morphological variants of CCSK as myxoid degeneration, microcysts formation and sclerosing pattern of extracellular hyalined collagen simulating osteoid were present in some regions. Immunohistochemical stains showed that tumor cells were diffusely positive for vimentin and bcl-2 antigen, and others negative. Conclusions CCSK is a rare type of renal neoplasm in childhood and its diagnosis relies mainly on histopathology and immunohistochemistry. It is important to be familiar with the morphological variants of CCSK to avoid confusion with other similar lesions, such as Wilm＇ s tumor, congenital mesoblastic nephroma, malignant rhabdoid tumor of kidney, primitive neuroectodermal tumor.
出处
《临床与实验病理学杂志》
CAS
CSCD
北大核心
2005年第5期539-542,共4页
Chinese Journal of Clinical and Experimental Pathology
关键词
肾肿瘤
肉瘤
透明细胞
免疫组织化学
诊断
鉴别
kidney neoplasms
sarcoma
clear cell
immunohistochemistry
diagnosis
differntial
