摘要
目的探讨肝细胞癌(HCC)瘤体周围供血动脉的时间平均血流速度(TVmean)与瘤体内微血管密度(MVD)的相关性,以及TVmean与瘤体细胞分化程度的关系,确定TVmean术前无创性估价HCC生物特性的价值。方法术前超声检测45例HCC患者瘤体周围供血动脉的TVmean,超声检测45例正常人肝组织内细小动脉的TVmean。观察术后HCC组织常规病理染色的细胞分化程度、免疫组织化学染色计数MVD,TVmean与MVD行直线相关分析。结果HCC瘤体动脉TVmean与MVD呈直线相关,相关系数r=0.794,回归方程为y=18.2764+1.5544x。依据TVmean≥21.3cm/s计算低分化HCC的阳性预测值为97.4%,阴性预测值为87.5%;TVmean<21.3cm计算高分化HCC的阳性预测值为88.5%,阴性预测值为97.3%;依据TVmean计算HCC细胞分化程度的可信度达89.5%。结论HCC瘤体动脉的TVmean可于术前估价瘤体的生长状态、细胞的恶性程度,为分析患者预后提供有用的依据。
Objective To evaluate the correlation between the mean of time blood flow velocity （TVmean） of feeding artery around hepatocellular carcinoma （ HCC ） and the microvessel density （ MVD ） in relation to tumor cell differentiation, and to evaluate the usefulness of TVmean as a noninvasive preoperative marker of biologic characteristic of HCC. Methods To measure TVmean of feeding arteries around the HCC in 45 patients before operation and TVmean of minute arteries in hepatic tissue in 45 normal subjects by ultrasonographic examination. Tumor cell differentiation grade was determined by routine histopathological staining. Tumor MVD was measured by immunohistochemical staining with monoclonal antibodies against F VIII RAg of excised HCC. Correlationship between TVmean of feeding arteries and MVD of HCC was studied. Results A linear correlation between TVmean of feeding arteries around the tumors of HCC and MVD of HCC tissue （ r = 0. 794, y = 18. 2764 ＋ 1. 5544x） was obtained. With TVmean ≥21.3 cm/s, the positive and negative predictive values of poorly differentiated HCC were 97.4% and 87.5%, respectively. With TVmean 〈21.3 cm/s, those of well differentiated HCC were 88.5% and 97.3%, respectively. The degree of reliability of calculating HCC cell differentiation according to TVmean was 89.5%. Conclusion Tumor growth and cellular differentiation, the two major factors affecting prognosis of HCC, may be evaluated by TVmean of feeding arteries around the tumor. It offers a useful preoperative information for predicting orognosis of HCC oatients.
出处
《中华肿瘤杂志》
CAS
CSCD
北大核心
2005年第9期538-540,共3页
Chinese Journal of Oncology
