摘要
目的:探讨中国人群中细胞间黏附分子1(ICAM1)基因K469E多态性与缺血性脑血管病的相关性。方法:收集112例缺血性脑血管病患者(短暂性脑缺血发作36例,脑梗死76例)和105例对照者,用聚合酶链反应和限制性片段长度多态性分析确定其基因型。结果:病例组ICAM1KK基因型频率为0.527,K等位基因频率为0.728,与对照组(分别为0.400和0.610)相比有显著差异(OR=1.71;95%CI1.14～2.57,P=0.009)。亚组分析表明,短暂性脑缺血发作亚组与对照组之间KK基因型频率无明显差异,而脑梗死亚组与对照组则有明显差异。结论:ICAM1469KK基因型可能是中国人脑梗死的一个独立危险因素。
Objective： To explore the correlation between intercellular adhesion molecule-1 （ICAM-1） gene K469E polymorphism and iscbemic cerebrovascular disease （ICVD） in Chinese population. Methods： One hundred and twelve patients with ICVD （36 TIAs and 76 cerebral infarctions） and 105 control subjects were recruited. Its genotype was determined by the polymerase chain reaction and restriction fragment length polymorphism analysis. Results： The frequencies of KK genotype and K allele in the ICVD group were 0. 527 and 0. 728, respectively, compared with those of the control group （0. 400 and 0. 610, respectively）, there was significant difference （OR = 1.71, 95% CI 1.14-2. 57; P =0. 009）. The subgroup analysis suggested that there was no significant difference between the TIAs subgroup and the control group in the frequencies of KK genotype, while there was significantly difference between the cerebral infarction subgroup and the control group. Conclusions： ICAM-1 469KK genotype may be an independent risk factor for cerebral infarction in Chinese population.
出处
《国外医学（脑血管疾病分册）》
2005年第8期575-579,共5页
Foreign Medical Sciences Cerebrovascular Diseases
