摘要
[目的]探讨丹酚酸B对心肌细胞(CM)抗缺氧损伤保护作用的途径。[方法]基于缺氧预适应的保护机制,通过缺氧/复氧的CM损伤模型,利用蛋白激酶C(PKC)抑制剂这一工具药,观察丹酚酸B对心肌细胞预适应在PKC途径中的作用,探讨丹酚酸B对心肌细胞保护的机制。[结果]丹酚酸B预适应可产生预适应样的保护作用,并且能促进被抑制的缺氧预适应(HPC)效应重现。[结论]丹酚酸B预适应与HPC具有相类似的细胞保护效应,可增强心肌细胞对随后较长时间缺氧/复氧损伤的耐受性,其机制可能是通过激活蛋白激酶C通路实现的。
[Objective] To discuss on Sal B protective effect pathway on cardiac muscle cell against injury due to hypoxia. [Methods] To observe the Sal B effect on cardiac muscle in the pathway of protein kinase C（PKC）. To discuss on the mechanism of cell protection about Sal B. To establish the CM injury model due to hypoxia and oxygen-recovery by using PKC depressantia. [Result] The accommodation in advance of Sal B may produce the protective effect of pre-adapting sample. The Sal B can promote the effect recovery of hypoxia preconditioning（HPC）. [Conclusion] The accommodation in advance of Sal B and HPC had similarly cell protection effect. The Sal B may enhance the toleration of injury due to hypoxia and oxygen-recovery by activating protein kinase C pathway in the later time.
出处
《天津中医药》
CAS
2005年第5期420-422,共3页
Tianjin Journal of Traditional Chinese Medicine
基金
天津市自然科学基金资助项目(013612711)
关键词
丹酚酸B
预适应
心肌细胞
蛋白激酶C
the accommodation in advance of Sal B
cardiac muscle cell
protein kinase C
