摘要
目的探讨丙泊酚持续恒速输注在大鼠无肝期前后血药浓度变化规律、肝外代谢、肺脏对丙泊酚肝外代谢的作用。方法通过左颈深静脉持续恒速输注丙泊酚,于分离肝门时、肝门阻断即刻、肝门阻断15、30、60min等时间点,同时从右侧颈深动、静脉分别采血(100μl),采用高效液相色谱荧光法(HPLC)检测丙泊酚血药浓度。结果颈深静脉或颈深动脉丙泊酚血药浓度各时相点间比较,肝门阻断15、30、60min时的血药浓度比阻断前和阻断即刻明显升高(P<0.01),但三者间没有显著性差异(P>0.05);颈深静脉与颈深动脉丙泊酚血药浓度比较,任何时刻没有显著性差异(P>0.05)。结论肝脏是丙泊酚主要代谢器官,丙泊酚存在肝外代谢,肺脏不是丙泊酚肝外代谢的主要器官。
Objective To observe the changes of propofol blood concentrations in rat during anhepatic phase by continuous steady-rate infusion to confirm the extrahepatic metabolism of propofol and to show the effect of lungs for propofol in the extrahepatic metabolism. Methods Continuous steady-rate transfuse propofol by left deep cervical vein, blood samples（100μl） were taken simultaneously from right the deep cervical artery and vein at the fllowing times： hepatic portal dissociation,immediate devascularization of the hepatic portal, 15min and 30min and 60min post-devascularization of the hepatic portal, propofol blood concentrations was analysed by HPLC. Results At 15min. 30min and 60min post devascularization of the hepatic portal,the propofol blood concentrations in the right deep cervical artery and vein were significantly higher than those the times of hepatic portal dissociation and immediate devascularization of the hepatic portal（P〈0.01 ）, the blood concentrations of propofol were no significantly differences at the three times of post devascularization of the hepatic portal （P〉0.05）. The blood concentrations of propofol in the deep cervical between artery and vein were no significantly differences at any times（P〉0.05）. Conclusion The liver is main organ of propofol metabolism. Extrahepatic metabolism of propofol is existence. Lung is not main organ of propofol extrahepatic metabolism.
出处
《重庆医学》
CAS
CSCD
2005年第10期1485-1486,共2页
Chongqing medicine
关键词
丙泊酚
无肝期
肝外代谢
propofol
anhepatic phase
extrahepatic metabolism
