摘要
腺相关病毒(adeno-associated virus,AAV)作为基因治疗载体近年来备受关注,但因其特殊的生物学性状限制了AAV在基础和临床实验中的研究。通过在AAV的包装、生产和纯化中采取新的方法和解决AAV转导中的限速步骤使AAV载体的应用在基因治疗中具有更广阔的前景。
Adeno-associated virus （AAV） vectors show great promise for gene therapy. The extensive application of this vector system in the basic medical sciences and clinical practice, however, is limited by their biological properties. This study explored the possibilities of expanding their use by introducing new techniques of packaging, production, purification and speeding-limiting method in AAV transduction.
出处
《医学分子生物学杂志》
CAS
CSCD
2005年第5期395-398,共4页
Journal of Medical Molecular Biology
关键词
腺相关病毒
载体
基因治疗
adeno-associated virus （AAV）
vector
gene therapy
