摘要
以羟基磷灰石为原料,镁、铝酸式磷酸盐为粘结剂,采用有机泡沫浸渍法制备骨组织工程羟基磷灰石多孔支架。扫描电镜(SEM)观察表明,高温煅烧的支架较好地复制了泡沫的三维结构孔隙特征,可满足组织工程对支架结构方面的要求。XRD分析表明,在1150℃下煅烧时间较短时,支架由HA和Ca7Mg2P6O24组成,煅烧时间较长时,支架由(Ca,Mg)3(PO4)2组成,没有发现CaO的衍射峰。体外细胞与支架复合培养研究表明,支架具有良好的生物相容性,并且表现出一定的降解性能。
The porous scaffolds for bone tissue engineering were prepared by foam impregnation. The magnesium and aluminum acid phosphates were used as bonder and the hydroxyapatite （（Ca10 （PO4）6 （OH）2,HA） powder as raw materials. Scanning electron mlcroscopy（SEM） examination indicated that the 3D interconnected porous structure of the organic foam was replicated well by the scaffolds calcined at high temperature and the structural requirement of tissue engineering was satisfied. XRD analysis showed that the scaffold was composed of HA and Ca7Mg2P6O24 while calcined at 1150℃ for shorter time and of （Ca,Mg）a（PO4）2 when the time prolonged to 2 h. There was no peak of CaO found in the scaffolds by XRD. According to the culture in vitro, the scaffold possesses good biocompatibility and certain degree of degradability.
出处
《生物医学工程学杂志》
EI
CAS
CSCD
北大核心
2005年第5期985-989,共5页
Journal of Biomedical Engineering
基金
江苏省高技术项目(BG2001033)
日本板梢子公司海外基金
