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17β-雌二醇对氧化型低密度脂蛋白损伤的内皮功能的保护作用

Protective effects of 17β estradiol on endothelial function injured by oxidized low density lipoproteins 1
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摘要 目的:研究17β雌二醇对氧化型低密度脂蛋白及其主要成分溶血磷脂酰胆碱(LPC)损伤的内皮功能的保护作用.方法:在兔离体主动脉环用苯福林收缩血管后,观察氧化型LDL及LPC对血管舒张功能的作用.结果:17β雌二醇显著减轻氧化型LDL及LPC对内皮舒张功能的损伤,并呈剂量依赖性.但吲哚美辛可拮抗17β雌二醇的这种保护作用.结论:17β雌二醇对氧化型LDL或LPC损伤的内皮功能具保护作用,其作用可能与刺激依前列醇的产生有关. IM: To test the protective effects of 17β estradiol against endothelial cell damages due to oxidized low density lipoproteins (LDL) and lysophosphatidylcholine (LPC), a principal component of oxidized LDL. METHODS: After the tension was increased by phenylephrine, the effects of oxidized LDL or LPC on the vasorelaxation responses to acetylcholine (ACh) were investigated in the isolated rabbit thoracic aortas. RESULTS: 17β Estradiol attenuated the inhibition of vasorelaxation responses to ACh by oxidized LDL or LPC in a concentration dependent manner. However, the protective effect of 17β estradiol was partially attenuated by indometacin (10 μmol·L -1 ), a cyclooxygenase inhibitor. CONCLUSION: 17β Estradiol possesses protec ̄tive effects on the endothelium against injury elicited by oxidized LDL or LPC, which may be related to its stimulation of epoprostenol production.
出处 《中国药理学报》 CSCD 1996年第3期252-255,共4页 Acta Pharmacologica Sinica
关键词 低密度 脂蛋白 溶血磷脂酰胆碱 雌二醇 血管内皮 LDL lipoproteins lysophos ̄phatidylcholines estradiol vascular endothelium indomethacin thoracic aorta phenylephrine
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  • 1李元建,中国药理学与毒理学杂志,1988年,2卷,161页 被引量:1
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