摘要
目的:研究17β雌二醇对氧化型低密度脂蛋白及其主要成分溶血磷脂酰胆碱(LPC)损伤的内皮功能的保护作用.方法:在兔离体主动脉环用苯福林收缩血管后,观察氧化型LDL及LPC对血管舒张功能的作用.结果:17β雌二醇显著减轻氧化型LDL及LPC对内皮舒张功能的损伤,并呈剂量依赖性.但吲哚美辛可拮抗17β雌二醇的这种保护作用.结论:17β雌二醇对氧化型LDL或LPC损伤的内皮功能具保护作用,其作用可能与刺激依前列醇的产生有关.
IM: To test the protective effects of 17β estradiol
against endothelial cell damages due to oxidized low density
lipoproteins (LDL) and lysophosphatidylcholine (LPC), a principal
component of oxidized LDL. METHODS: After the tension was increased
by phenylephrine, the effects of oxidized LDL or LPC on the
vasorelaxation responses to acetylcholine (ACh) were investigated in
the isolated rabbit thoracic aortas. RESULTS: 17β Estradiol
attenuated the inhibition of vasorelaxation responses to ACh by
oxidized LDL or LPC in a concentration dependent manner. However,
the protective effect of 17β estradiol was partially attenuated by
indometacin (10 μmol·L -1 ), a cyclooxygenase inhibitor.
CONCLUSION: 17β Estradiol possesses protec ̄tive effects on the
endothelium against injury elicited by oxidized LDL or LPC, which may
be related to its stimulation of epoprostenol production.
出处
《中国药理学报》
CSCD
1996年第3期252-255,共4页
Acta Pharmacologica Sinica
关键词
低密度
脂蛋白
溶血磷脂酰胆碱
雌二醇
血管内皮
LDL lipoproteins
lysophos ̄phatidylcholines
estradiol
vascular endothelium
indomethacin
thoracic aorta
phenylephrine