期刊文献+

蛋白质折叠过程中的长短程作用研究 被引量:2

The studying of long- and short-range interactions in the protein folding
原文传递
导出
摘要 基于蛋白质二维HP非格模型和改进的模拟退火算法研究了长短程作用在蛋白质折叠过程中的作用。通过试验得出1ECD、2RNS、1PHT、1WBC等序列的折叠构型,并根据PDB中所提供的上述序列的结构信息,具体讨论了长程作用对蛋白质构型的影响,说明了:长程作用在三级结构的形成和稳定中,位于诸多影响因素的首位。 Based on the protein 2-dimension HP off-lattice model and the improved simulated annealing algorithm, this paper discusses the respective roles of short- and long interactions in protein folding, the configurations of 1ECD ,2RNS, 1PHT, 1WBC are obtained, and with their structure information in the PDB, the influence of long-range interactions is discussed. The results show that for the folding and stability of proteins, long-range interactions are the main determinants.
出处 《计算机与应用化学》 CAS CSCD 北大核心 2005年第10期832-836,共5页 Computers and Applied Chemistry
基金 国家自然科学基金资助项目(90103033)
关键词 长短程相互作用 蛋白质折叠 模拟退火算法 二维HP非格模型 long and short-range interactions, proteins folding, simulated annealing algorithm, 2-dimension HP off-lattice model
  • 相关文献

参考文献21

  • 1Anders Irb(a)ck, Erik Sandelin, Local interactions and protein folding:a model study on the square and triangular lattices. Journal of Chemical Physics, 1998, 108 (5) :2246 -225O. 被引量:1
  • 2Gromiha MM and Sclvaraj S. Comparison between longrange interactions and contact order in determining the folding rate of two-state proteins:application of long-range order to folding ate prediction. J Mol Bio, 2001, 310:27 -32. 被引量:1
  • 3Wang LH and Zhou HB. Respective roles of short- and long-range interactions in protein folding. Wuhan University Journal of Natural Science, 2004, 6:962 - 968. 被引量:1
  • 4Stillinger FH, Head-Gordon and Hirshfeld CL. Toy model for protein folding. Physical Review E, 48:1469 - 1477. 被引量:1
  • 5Stillinger FH. Collective aspects of protein folding illustrated by a toy model. Physical Review E, 1992,52 ( 32 ) :2872- 2877. 被引量:1
  • 6.[EB/OL].http:∥www. rcsb. org/pdb.,. 被引量:1
  • 7Sucha Sudarsanam. Structural diversity of sequentially identical subsequences of proteins: Identical octapeptides can have different conformations. PROTEINS: Structure Function and Genetics, 1998, 30:228 - 231. 被引量:1
  • 8Wolfgang Kabsch and Christian Sander. On the use of sequence homologies to predict protein structure: Identical pentapeptides can have completely different conformations.Biochemistry, 1984, 81: 1075 - 1078. 被引量:1
  • 9Gromiha MM and Selvaraj S. Importance of long-range interaction in protein folding. Biophysical Chemistry, 1999,77:49 - 68. 被引量:1
  • 10Michacl Gromiha and Selvaraj S. Importance of long-range interaction for determining the folding rate and transition state structures of two-state proteins. Genome Informatics,2002, 50:48 - 349. 被引量:1

二级参考文献28

共引文献50

同被引文献9

引证文献2

相关作者

内容加载中请稍等...

相关机构

内容加载中请稍等...

相关主题

内容加载中请稍等...

浏览历史

内容加载中请稍等...
;
使用帮助 返回顶部