摘要
目的:探讨核因子kB(NF-kB)、肝素结合性表皮生长因子(HB-EGF)在人体正常、炎症、妊娠输卵管壶腹部黏膜表达及作用。方法:利用免疫组化法和图像分析技术检测NF-kB、HB-EGF在人输卵管黏膜的表达。结果:人体正常、炎症、妊娠输卵管壶腹部黏膜上皮细胞均有NF-kB和HB-EGF表达,炎症组和妊娠组NF-kB的表达与正常组比较均显著增强,差异有极显著性(P<0·01);HB-EGF的表达炎症组较正常组增强,差异有显著性((P<0·05),妊娠组较正常组显著增强,差异有极显著性(P<0·01)。结论NF-kB、HB-EGF表达于输卵管壶腹部黏膜,参与输卵管生理、病理过程。
Objective： To investigate the expression of nuclear factor kappa B （ NF- kB） and heparin- binding epidermal growth factor（ HB -EGF） in oviduct ampullar mucosa of normal, inflammatory and tubal ectopic pregnancy. Methods： The expression and localization of NF - kB and HB - EGF were determined with the immunohistochemical method and the image analysis. Results： NF - kB and HB - EGF were detected in all state of oviduct ampullar mucosa. The expression level of NF - kB was significantly higher in oviduct ampullar mucosa of inflammatory and tubal ectopic pregnancy than that in the normal group （P 〈 0. 01 ）. Compared to the human normal group, the expression level of HB - EGF was significantly higher in oviduct ampullar mucosa of inflammatory and tubal ectopic pregnancy （P 〈 0. 05 ）. Conclusion： The expression of NF - kB and HB - EGF play an important role in pathology and physiology of oviduct.
出处
《中国计划生育学杂志》
北大核心
2005年第9期535-537,共3页
Chinese Journal of Family Planning
