摘要
目的:探讨MR体积测量技术评价帕金森病(Parkinson’sdiseasePD)患者基底节区(尾状核,壳核,苍白球)、黑质体积改变的价值。方法:采用3·0TMR测量早、晚期PD患者和年龄匹配正常人对照组全脑体积、尾状核、壳核、苍白球、黑质体积。对患者进行PD统一评分量表(UPDRS)第Ⅱ、Ⅲ、Ⅴ部分评分。评分结果与患者基底节区、黑质体积行相关性分析。结果:早、晚期PD患者壳核体积较正常人分别下降12·5%(P=0·004)和26·5%(P<0·001),晚期患者较早期患者下降16·0%(P=0·002)。晚期患者苍白球体积较正常人下降19·2%(P=0·023)。PD患者壳核体积与Hoehn&Yahr分级呈负相关(r=-0·741,P<0·001)。结论:MR体积测量技术是评价PD患者基底节区、黑质体积改变的一种可靠的方法,能为PD辅助诊断提供有效的影像学指标。
Aim：To explore the value of MRI based volumetry in estimating the volumes of the caudate, putamen, globus pallidus, substantia nigra of Parkinson＇ s disease （PD） patients. Methods： The volumetric measurements of the total brain volume, caudate, putamen, globus pallidus, substantia nigra in PD patients and the controls were performed on a 3.0T MR scanner. The patients underwent the assessment of the sub scale Ⅱ、Ⅲ、 and Ⅴ of the Unified Parkinson＇s Disease Rating Scale（UPDRS） .Correlation analysis was made between the volumetric measurements and UPDRS assessment.Results： Compared to controls, the early stage PD patients and late stage PD patients had smaller volume of the putamen which decreased respectively 12.5% （P =0.004） and 26.5% （P 〈 0.001 ）. The late stage PD patients had even smaller volume of the putamen 16% （ P = 0.002） than the early stage ones. The volume of the globus palldus in the late stage PD patients decreased 19.2 % （ P = 0.023 ）, compared to controls. The volume of the putamen of PD patients was negatively correlated with the H＆Y range（ r = -0.741, P 〈 0.001 ）. Conclusion：The MRI based volumetry is a reliable method in the assessment of the morphological changes of the basal ganglia and substantia nigra in PD patients. This method provides an imaging predictive marker in the diagnosis of PD.
出处
《中国临床神经科学》
2005年第3期273-278,共6页
Chinese Journal of Clinical Neurosciences
关键词
帕金森病
磁共振成像
黑质
基底节
Parkinson＇ s disease（PD）
magnetic resonance imaging（MRI）
substantia nigra
basal ganglia
