摘要
目的分析泌尿道感染病原菌的分布及耐药情况,指导临床合理用药。方法对2003￣2004年我院住院及门诊患者413份尿培养标本及其分离出的株细菌进行鉴定和药物敏感实验。结果共分离泌尿道感染菌株227株,以大肠埃希菌为主,占43.2%;其次为粪肠球菌、阴沟肠杆菌、变形杆菌、粘质沙雷氏菌、无乳链球菌、凝固酶阴性葡萄球菌、肺炎克雷伯菌、屎肠球菌、金黄色葡萄球菌、铜绿假单胞菌等;大肠埃希菌和肺炎克雷伯菌对于头孢二代和头孢三代耐药率低于30%,但大肠埃希菌对于左氧沙星和氧氟沙星的耐药率高于50%。阴沟肠杆菌和粘质沙雷氏菌对本次实验中抗生素的耐药率大于40%。屎肠球菌的耐药性高于粪肠球菌。未见对万古霉素的耐药株。凝血酶阴性葡萄球菌和金黄色葡萄球菌对苯唑西林的耐药率分别为50.0%和28.6%。结论临床医师在经验用药前,应送尿培养,有利于合理用药。
Objective To investigate the bacteria distribution and drug resistance in urinal tract infection. Methods 413 urine specimens were collected from inpatient and outpatient departments of hospital from 2003 to 2004. Bacteria were identified and the disc diffusion test was performed. Results 277 isolated strains of urinary specimen, Escherichia coil rated the first （43.2%）,followed with Enterococcus , Enterococcus faecalis, E. cloacae. Proteus spp, Serratia spp, Streptococcus Group B, coagulase negative staphylococcus. Klebsiella pneumoniae, Enterococcus faecium, Staphylococcus aureus, Pseudomonas aeruginosa. The drug resistance ratio of Escherichia coil and Klebsiella pneumoniae to the second cephalosporin and the third cephalosporin were lower than 30%,but Escherichia coil to levofloxacin and of loxacin was higher than 50%. E. cloacae and Serratia spp were higher than 40% to drug in this study. Enterococcus faecium was more resistance than Enterococcus faecalis, they are susceptive to vancomycin. Coagulase negative staphylococcus and staphylococcus aureus to oxacillin respective were 55.0% and 30.8%. Conclusion Urine culture should be done before clinician experience using drug, it is helpful to apply antibacterial reasonable.
出处
《中国现代医药杂志》
2005年第4期44-46,共3页
Modern Medicine Journal of China
