摘要
已知免疫功能,特别是T_H/T_S比值失衡与肿瘤的形成、扩展、转移密切相关。本文报道以OKT3,OKT4,OKT8单克隆抗体(MA6)检测进展型胃癌病人外周血中T细胞亚群,探讨其与临床病情的相关。 一、对象与方法 37例胃癌患者均经病理证实为不同分化程度的腺癌;男27例、女10例,平均59.9±14.9岁。晚期胃癌30例,男21例、女9例,平均62.4±12岁;
Peripheral T lymphocyte subsets from 28 cases of late stage and 7 cases of resect-able of advanced gastric cancer and also 23 cases of healthy persons were determinedby OKT monoclonal antibodies. In compare with healthy group OKT 4^+ in late stageof advanced cancer group is lower (42±9.4%), OKT 8^+ is markedly elevated (39.4±5.7%), and OKT 4^+/OKT 8^+ ratio (1.1±0.3) is significantly depreesed (P<0. 001).The criteria from resectable gastric cancer showed statistically significant differencetoo (P<0.05). The result suggests that abnormality of peripheral T subsets is closelyrelated to the clinical course.
出处
《肿瘤》
CAS
CSCD
北大核心
1989年第4期160-161,共2页
Tumor
