摘要
目的:研究p53蛋白和Ki-67在恶性纤维组织细胞瘤(malignant fibrous histi-ocytoma,MFH)组织中的表达及其临床意义。方法:应用免疫组化SP法检测50例MFH中p53和Ki-67的表达。结果:p53蛋白和Ki-67在MFH中表达阳性率分别为32·0%(16/50)和56·0%(28/50);在有复发转移的患者中,p53蛋白和Ki-67的阳性率分别为48%(12/25)和68%(17/25);在无复发转移的患者中,p53蛋白和Ki-67的阳性率分别为16·0%(4/25)和40·0%(10/25);生存期<5年的患者中,p53蛋白和Ki-67的阳性率分别为48·1%(13/27)和70·4%(19/27),生存期>5年的患者中p53蛋白和Ki-67的阳性率分别为17·4%(4/23)和39·1%(9/23)。p53蛋白和Ki-67与患者的复发转移及生存期显著相关,P<0·05。p53蛋白与Ki-67的表达关系密切,P<0·05。结论:p53蛋白和Ki-67的高表达与MFH的复发转移及患者生存期相关,两者的表达关系密切,并可作为MFH患者预后判断的两个指标。肿瘤防治杂志,2005,12(19)
OBJECTIVE： To study p53 protein and Ki-67 expressions in patients with malignant fibrous histioeytom-MFH and their clinical significance. METHODS： The SP immunohistochemical method was employed to examine the expressions of p53 protein and Ki-67 in 50 cases of MFH. RESULTS： The positive rates of p53 protein and Ki-67 expressions were 32.0% （16/50） and 56.0% （28/50）. respectively. In cases of recurrence and metastasis, the positive rates of p53 protein and Ki-67 expressions were 48.0% （12/25） and 68.0%（17/25）, respectively. In cases of nonrecurfence and nonmetastasis, the positive rates of p53 protein and Ki-67 expressions were 16.0%（4/25） and 40.0%（10/25）, respectively. In less than 5 year survival cases, the positive rates of p53 protein and Ki-67 expressions were 48. 1%（13/27） and 70.4%（19/27）. In over 5 year survival cases, the positive rates of p53 protein and Ki-67 expressions were 17.4 % （4/23） and 39. 1 % （9/23）. The expressions of p53 protein and Ki-67 were related to the recurrence and metastasis of MFH, and survival rate of the patients, P〈0.05. The expression of p53 protein was closely related to that of Ki-67,P〈0. 05. CONCLUSIONS： The over expressions of p53 and Ki-67 are related to recurrence and metastasis of MFH, and survival rate of the patients. The expressions of both of them are colosly related and can serve as two markers of judging prognosis of the patients.
出处
《肿瘤防治杂志》
2005年第19期1492-1494,共3页
China Journal of Cancer Prevention and Treatment
