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抗T淋巴细胞单克隆抗体治疗再生障碍性贫血的临床研究 被引量:2

CLINICAL STUDY ON THE TREATMENT OF APLASTIC ANEMIA WITH MONOCLONAL ANTI HUMAN T LYMPHOCYTE ANTIBODY
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摘要 用抗人T淋巴细胞单兔隆抗体SMU3(抗CD3),SMU8(抗CD8)治疗32例再生障碍性贫血,基本治愈6例,缓解7例,明显进步11例,无效8例,有效率75%(24/32)。治疗前T淋巴细胞业群CD4/CD8比例倒置,淋巴细胞表面HLA-DR抗原表达增高;治疗后CD4/CD8比例恢复正常,HLA-DR表达降低。无血清病及血细胞减少等严重毒副作用。 The monoclonal anti human T lymphocyte antibodies SMU3 (anti CD3) and SMU8 (anti CD8) were used to treat 32 patients with aplastic anemia. The results showed that 6 patients were cured, remission and good response were achieved in 7 and 11 respectively. The other 8 patients had no response. The effective rate was 75% (24/32). The T cell subsets CD4/CD8 ratio was inverse and expression HLA DR antigen on the lymphocytes surface was higher before SMU3 and SMU8 therapy, and they returned to normal after therapy. No severe toxic and side effect such as serum disease or hematocytopenia was found.
出处 《解放军医学杂志》 CAS CSCD 北大核心 1996年第3期171-173,共3页 Medical Journal of Chinese People's Liberation Army
关键词 再生障碍性贫血 抗淋巴细胞 单克隆抗体 治疗 monoclonal antibody T lymphocyte anemia,aplastic therapy
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  • 1宋玉华,中华血液学杂志,1986年,7卷,9期,539页 被引量:1
  • 2陈泽锦,中华血液学杂志,1992年,13卷,233页 被引量:1
  • 3张之南,血液病诊断及疗效标准,1991年 被引量:1
  • 4刘春明,免疫学杂志,1989年,5卷,180页 被引量:1
  • 5唐佩弦,造血细胞培养技术,1985年 被引量:1

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