摘要
目的:探讨美托洛尔降低急性心肌梗死(AMI)死亡率的可能机制.方法:60例AMI患者随机均分为治疗组和对照组,治疗组在对照组常规治疗的基础上应用美托洛尔,比较2组恶性心律失常和再发心肌梗死的发生情况以及QT离散度、左室重构指标的变化.结果:与对照组比较,治疗组恶性心律失常、再发心肌梗死的发生例数明显降低(P＜0.01～0.05),QT离散度显著减少(P＜0.01),左室重构变化更小(P＜0.05).结论:美托洛尔可能通过降低恶性心律失常及再发心肌梗死的发生、减少QT离散度、抑制左室重构等方面降低AMI的死亡率.
OBJECTIVE： To investigate the possible mechanism of metoprolol in reducing the mortality of acute myocardial infarction （AMI）, METHODS： 60 AMI subjects were randomly divided into two groups, the treatment group was administered with metoprolol besides the conventional therapy administered in the control group, the two groups were compared in respects of the occurrences of malignant arrhythmia and the relapse of myocardial infarction, QT divergency （QTd） and left ventricular remodeling （LVRM） indexes, RESULTS： Compared with the control group, the malignant arrhythmia and myocardial infarction relapse cases were significantly decreased in the treatment group（P〈0.01～0.05）, QTd was significantly reduced（P〈0.01） and LVRM change was significantly less than those in the control group （P〈0.05）. CONCLUSION： The mortality of AMI can be reduced by metoprolol through reducing the occurrence of malignant arrhythmia and the relapse of myocardial infarction, decreasing QTd, inhibiting LVRM, etc.
出处
《中国药房》
CAS
CSCD
北大核心
2005年第18期1408-1410,共3页
China Pharmacy
关键词
美托洛尔
急性心肌梗死
机制
Metoprolol
Acute myocardial infarction
Mechanism
