摘要
IL-6水平在脓毒症过程中对判断预后具有重要意义。NF—κB是脓毒症IL-6表达的主要调控因子，本研究探讨了解脓毒症导致MODSE过程中，各器官损害的时序及程度变化，确定MODSE发生的早期预警指标，分析脓毒症过程中各器官NF—κB---IL-6炎性通路活性的随龄变化，对感染导致MODSE的可能启动机制做初步的研究。
Infection is a major cause of multi-organ-dysfunction, senility is an independent risk factor of poor outcome in sepsis related MODS. Different studies on the pathogenesis and development of MODS came to different explanations. The serum interleukin-6 level is a strong predictor of poor outcome in sepsis. Nuclear factor-kappa B is an important regulatory factor of IL-6 transcription in sepsis. In this study, we aimed at researching the sequence and severity of organ injury and establishing some early warning index of sepsis related MODS of elderly （MODSE）. We also tried to study the possible role of age related NF-κB binding activity changing in initiation of sepsis related MODSE.
出处
《世界急危重病医学杂志》
2005年第5期890-892,共3页
internationl journal of emergency and critical care medicine
关键词
MODSE
器官损害
结合活性
多脏器功能衰竭
脓毒症
随龄改变
NF
启动
感染
aging
sepsis
multi-organ-dysfunction syndrome in elderly
interleukin-6
nuclear factor kappa-B
cecum ligation and puncture
