摘要
目的观察祛瘀消斑胶囊对实验性动脉粥样硬化斑块组织学构成的影响。方法20只兔喂以高胆固醇饲料,12周末16只造型兔随机分为自然消退组和中药组,于实验开始、12周末和24周末超声测量腹主动脉内膜中层厚度(IntimaMediaThickness,IMT)、内中膜及外膜图像平均回声强度(AverageImageIntensity,AII),并和病理检测结果对比。结果中药组AII的校正值(AIIc%)较造型后测值显著增大(P<0.01);造型后,自然消退组和中药组形态学检查有明显差异。结论祛瘀消斑胶囊能在一定程度上改变斑块的组织学构成,起到稳定斑块的作用。
Objective To investigate the effect of “Quyu Xiaoban Capsule” on atherosclerosis（AS） structure of rabbit. Methods Sixteen rabbits with AS were divided randomly into regression control group and Chinese medicine group. At the beginning, and at the 12^th and 24^th weeks of the experiment IMT and AIIc% of abdominal aorta were measured with high-frequency ultrasound. Abdominal aorta was also examined pathologically at the 24^th week. Results AIIc% in Chinese medicine group were significantly higher than that in regression control group（P 〈 0.01 ）. Conclusions It is suggested that “Quyu Xiaoban Capsule” can somewhat stabilize plaques by changing histological structure.
出处
《上海中医药大学学报》
CAS
2005年第3期34-35,共2页
Academic Journal of Shanghai University of Traditional Chinese Medicine
基金
山东省卫生厅"九五"重点攻关项目(9711)
