摘要
目的探讨鼻窦炎口服液对家兔实验性急性化脓性上颌窦炎的疗效。方法采用改良后的Hinni造模法建立家兔急性化脓性上颌窦炎模型。予以鼻窦炎口服液高、低剂量灌胃治疗,并设立空白组、模型组、西药(青霉素V钾灌胃)组作为对照。观察模型家兔血白细胞(WBC)计数及中性粒细胞(N)百分比、血清C-反应蛋白(CRP)浓度,光镜观察窦腔黏膜炎症情况及窦腔分泌物细菌培养。结果模型兔白细胞(WBC)计数及中性粒细胞(N)百分比增加,光镜下窦腔黏膜充血、水肿、纤毛脱落等。经鼻窦炎口服液低剂量治疗后,家兔白细胞(WBC)计数及中性粒细胞(N)百分比在正常范围,光镜下窦腔黏膜正常等,与青霉素V钾相比,无显著性差异。鼻窦炎口服液高剂量治疗后,上述病理改变有明显改善。结论鼻窦炎口服液的临床治疗量可消除急性化脓性鼻窦炎家兔全身及局部的炎症反应。
Objective To investigate the therapeutic effect of Bidouyan Oral Liquid （BOL） on acute suppurative maxillary sinusitis （ARMS） in rabbits, Methods Modified Hinni＇s method was used to inducing the ARMS rabbit models. The high and low - dosage of BOL was administered by gastric gavage and penicillin V was used for the positive medicine. The white blood cells （WBC） count, neutrophil percentage, serum C-reactive protein （CRP） level, inflammatory changes of mucosa of nasal sinuses under light microscope and bacteria culture of secretion in ARMS rabbit models were observed. Results Inflammatory changes were shown in the experimental ARMS rabbits as follows： white blood cells count and neutrophil percentage increased, mucosa of nasal sinuses congested and swollen with the exfoliation of pili. After the treatment with high - and low - dosage of BOL, the above parameters in the rabbits recovered to normal, the difference being insignificant compared with penicillin V. Conclusion BOL in clinical dose can control the general and local inflammatory reaction in ARMS rabbits.
出处
《中药新药与临床药理》
CAS
CSCD
2005年第5期336-339,共4页
Traditional Chinese Drug Research and Clinical Pharmacology
基金
四川省中医管理局资助项目(编号2000-52)
关键词
鼻窦炎口服液
急性化脓性上颌窦炎
白细胞计数
C-反应蛋白
细菌培养
Bidouyan Oral liquid
Acute suppuratixe maxillary sinusitis
White blood cells count
C-reactive protein
Bacteria culture
