摘要
以Ａｖｉａｎ鸡为实验对象，研究了神经内分泌免疫网络在传染性法氏囊病病毒（ＩＢＤＶ）弱毒免疫和强毒感染时发生的调节机制。结果表明，ＩＢＤＶ弱毒免疫能获得高滴度的血清ＩＢ－ＤＶ抗体。未免疫肉鸡感染ＩＢＤＶ强毒后会引起免疫功能抑制。ＩＢＤＶ攻毒后，肉鸡血浆皮质酮、ｃＧＭＰ升高，Ｔ淋巴细胞转化率、白介素－２活性明显降低。ＩＢＤＶ弱毒免疫肉鸡遭受ＩＢＤＶ强毒感染后，血浆ｃＡＭＰ和ｃＧＭＰ同时升高并呈现高阈平衡。ＩＢＤＶ攻毒前后，肉鸡血浆ＡＣＴＨ、皮质酮和免疫功能指标间有显著的相关性，提示外来病原入侵后，肉鸡垂体－肾上腺轴可调节免疫功能。
Avian chickens were used as experimental objects to study the regulation mechanism of network of immune neuroendocrine against IBDV. The results showed that the broilers immunized with attenuated IBDV could produce the specific antibody at high levels. The immunity of broilers was supressed if they infected with virulent IBDV. After infection of IBDV, the plasma corticosterone and cGMP levels increased significantly and the transformation rate of T lymphocyte and activity of interleukin 2 (IL 2) decreased significantly. The immunized broilers presented the high threshold balance of cAMP and cGMP after challenge of virulent IBDV. There were close relationships among plasma adrenocorticotropic hormone (ACTH), corticosterone, and immune function indeces, which suggested that when broilers were invaded by pathogens, the hypophysis adrenal axis could modulate immune function, i.e. improve specific immunity via supressing nonspecific immunity.
出处
《中国兽医学报》
CAS
CSCD
1996年第4期333-337,共5页
Chinese Journal of Veterinary Science
关键词
肉鸡
神经内分泌
免疫网络
IBDV
鸡病
network of immune neuroendocrine
infectious bursal disease virus (IBDV)
cAMP
cGMP
broiler
