摘要
目的研究尿I型胶原氨基末端肽(NTx)在早期预测妇女绝经期骨质疏松中的作用。方法63名绝经前妇女分成双侧卵巢切除组和卵巢未切除两组,分别在术前及术后3个月检测血清雌激素(E2)、促卵泡生成素(FSH)、碱性磷酸酶(AKP)和尿NTx/Cr值,比较其变化情况。结果卵巢切除组术后3个月血清E2明显下降,血清FSH和尿NTx明显升高,血清AKP无变化。卵巢未切除组,各项研究指标均无明显变化。结论作为一项骨吸收指标,双侧卵巢切除后3个月就能观察到尿NTx的变化,由此可早期了解绝经妇女骨吸收情况,早期预防骨质疏松症的发生。
Objective To investigate the effect of urinary N-telopwptide of type Ⅰ collagen （NTx） on early diagonosis of postmenopausal osteoporosis. Methods The subjects were 63 premenopausal women, including 30 bilateral ovariectomy（OVX） women and 33 only total hysterectomia women. Patients in both group were detected serum E2, FSH, AKP and NTx before operation and after three months of operation, and comparison made between the results and the consequences. Results The serum E2 level showed decrease significantly, while both serum FSH and NTx levels showed increase significantly in OVX group after three months of operation. There was non-significant change of serum AKP level in all groups. There was no statistically difference in all indices in the control group three months after operation. Conclusion The statistically difference in urinary NTx level can be detected three months after bilateral ovariectomy. So that bone loss in postmenopausal women can be detected early through NTx variation, and osteoporosis.
出处
《苏州大学学报（医学版）》
CAS
北大核心
2005年第4期644-646,共3页
Suzhou University Journal of Medical Science
