摘要
目的测定2型糖尿病(T2DM)患者和正常对照个体的血清脂联素(APN)水平和颈动脉内膜中层厚度(IMT),分析其变化特点及相关性。方法运用ELISA法测定38例T2DM患者和20名正常个体的血清APN水平,同时测定他们的IMT,分析所有研究对象的APN与IMT的相关性。结果T2DM患者血清APN水平显著低于正常对照组(P<0.05),IMT显著高于正常对照组(P<0.05),血清APN水平与IMT呈显著负相关(r=-0.30,P<0.05)。结论APN可能具有抗动脉粥样硬化的作用,APN是预防糖尿病大血管并发症的保护因素之一。
Objective To evaluate the levels of serum APN and IMT in type 2 diabetic patients and the control subjects. Methods The levels of serum APN were measured by ELISA in all 38 type 2 diabetic patients, meanwhile the levels of IMT also were measured. The relationship between APN and IMT were analysised in all studied subjects. Results The levels of serum APN in type 2 diabetic patients were significantly lower than that in the control subjects（P〈 0.05）. The levels of IMT in type 2 diabetic patients were significantly higher than that in control subjects （P 〈 0.05）. There was a negative correlation between serum APN and IMT in all studied subjects （r = -0.30, P 〈 0.05）. Conclusion APN is one of protective factors to prevent macrovascular complication in T2DM.
出处
《苏州大学学报（医学版）》
CAS
北大核心
2005年第4期627-629,共3页
Suzhou University Journal of Medical Science
