摘要
目的探讨角蛋白家族的特性及其基因的突变和异常表达与恶性肿瘤关系研究的最新进展。方法采用文献回顾的方法,对目前国内、外有关角蛋白家族的研究状况进行分析与综述。结果角蛋白家族是3种细胞支架蛋白(中间纤维蛋白、微管蛋白和微纤维蛋白)之一的中间纤维蛋白,具有维持细胞力学完整性及调节细胞周期作用。角蛋白mRNA基因的突变或角蛋白家族蛋白的过度表达,可使细胞周期紊乱或细胞力学完整性被破坏,从而发生相应疾病或恶性肿瘤。结论通过对角蛋白家族突变基因及角蛋白家族蛋白的异常表达的检测,可对一些恶性肿瘤或疾病进行诊断、分期和预后判断。
ObJective To investigate the recent studies on the biocharacters of keratin family （e. g. genetic, mutations and abnormal expressions） and their relationships with the malignant tumors. Methods The literatures of recent years on the biocharacters of keratin family （e. g. genetic mutations and abnormal expressions） and their relationships with the malignant tumors were reviewed. Results Keratin family is a kind of structural proteins in cell which plays an important role in cytomechanics and regulates cell-cycle. The mutations of keratin genes （mRNA） or the overexpression of keratin proteins would interfere with the order of cell-cycle or the integrity of cy- tomechanics, and lead to some diseases and malignant tumors finally. Conclusion The studies on biocharaters of keratin family （e. g. genetic mutations and abnormal expressions） are helpful in the diagnosis, staging and the eval- uation of prognosis of some diseases and cancers, e.g. liver cirrhosis, breast cancer, rectum carcinoma, etc.
出处
《中国普外基础与临床杂志》
CAS
2005年第5期527-529,共3页
Chinese Journal of Bases and Clinics In General Surgery
基金
国家杰出青年科学基金(编号:39925032)~~
关键词
角蛋白
直肠癌
恶性肿瘤
早期诊断
Keratin Rectal cancer Malignant tumor Early diagnosis
