摘要
目的探讨转化生长因子β1(TGF-β1)及其Ⅱ型受体(TGFβR-Ⅱ)在卵巢肿瘤中的表达及其意义。方法1998年7月至2001年12月哈尔滨医科大学第一临床医学院,采用SP免疫组化染色方法,对30例卵巢癌,30例卵巢良性上皮性肿瘤及30例正常卵巢组织中TGF-β1、TGFβR-Ⅱ的表达进行分析。结果卵巢癌组TGF-β1阳性率明显高于正常卵巢组(P<0·01),且二者的强阳性率比较差异有非常显著性意义(P<0·01);卵巢良性上皮性肿瘤中TGF-β1阳性率与正常卵巢组比较,两者的阳性率、强阳性率之间比较差异均无显著性意义(P>0·05)。卵巢癌组TGFβR-Ⅱ阳性率低于正常卵巢组(P<0·05),且两者的强阳性率之间差异有非常显著性意义(P<0·01);卵巢良性上皮性肿瘤中TGFβR-Ⅱ阳性率与正常卵巢组比较,两者的阳性率、强阳性率之间差异均无显著性意义(P>0·05),与卵巢癌组比较,两者的阳性率之间差异有显著性意义(P<0·05),但强阳性率之间差异无显著性意义(P>0·05)。结论在卵巢癌中TGF-β1呈过度表达,使得其抑制癌细胞生长的作用丧失。在卵巢癌中TGFβR-Ⅱ失表达,使肿瘤细胞有效地逃避了机体的抑制。
Objective To study the expression and significance of transforming growth factor β1 （TGFβ1） and its receptor If（TGFβR-Ⅱ） in ovarian tumor. Method The S-P immunohistochemical staining method was used to detect 30 ovarian cancers,30 benigh ovarian tumors and 30 normal ovarian tissues. Results There were great differences in the two groups’ positive rate and strong positive rate（ P 〈 0. 01 ） between cancer group and normal tissue group. There was no difference in benign epithelial tumor group＇s positive rate and strong positive rate towards normal tissue group （ P 〈 0. 01 ）. There were differences in positive rate between the benign tumor group and the cancer group （P 〈 0.01 ）, but their strong positive rate had no difference（ P 〉 0. 05 ）. The positive rate of TGFβR-Ⅱin cancer group and normal tissue group had differences （P 〈 0. 05 ）, and their strong positive rates had great difference （ P 〈 0. 01 ）. There was no difference in benign epithelial tumor group＇s positive rate or strong positive rate towards normal tissue group. In comparison with cancer group, their positive rates had differences（ P 〈 0. 05 ）but strong positive rates had no difference （P 〉 0. 05 ）. Conclusion TGF-β1 is over ex- pressed in ovarian cancer, TGF-β1 loses its inhibition of cancer cell through other biological function. TGFβR-Ⅱ is lost in cancer, then its message can＇t be transferred, thus rendering the cancer cells resistant to growth inhibition by organism.
出处
《中国实用妇科与产科杂志》
CAS
CSCD
北大核心
2005年第9期542-544,共3页
Chinese Journal of Practical Gynecology and Obstetrics
