摘要
进行开放性自身对照临床试验，验证添加拉莫三嗪治疗顽固性癫痫６３例的疗效和安全性。以治疗前３个月的发作频度为基础，治疗后观察３～１５个月。未服丙戊酸钠的成人平均维持量为２８９ｍｇ／ｄ；已服者为１４２ｍｇ／ｄ。癫痫全部发作类型的平均发作频度在治疗１２周时比治疗前降低３１％，发作频度减少≥５０％者占４１％，发作消失者占１４％。全身强直－阵挛型和全面性发作者疗效最佳，发作频度减少≥５０％者，在１２周时分别达６１％和６０％，平均发作频度分别减少５９％和３６％。治疗４～１５个月者５１例，疗效和近期相仿。Ｌｅｎｎｏｘ－Ｇａｓｔａｕｔ综合征的５例患者治疗１２周后，３例发作减少≥９６％。脑电图高度和中度不正常患者的比例，由治疗前的５０％，下降为１７％。拉莫三嗪副作用小，皮疹为主要表现，停药后消失。
patientswithrefractoryepilepsyenteredanopenadd-onstudywithlamotrigine(LTG)toevaluateitseficacyandsafety.Thetreatmentperiodwas3to15monthswiththemeanmaintenancedosageof289mg/dayexceptthosereceivingvalporate,whohad142mg/day.At3months,LTGproducedstatisticalysignificantmedianreductioninseizurefrequencyascomparedwiththepre-LTGperiod(3monthsbaseline),thatwas31%fortotalseizurecounts,59%foridio-pathicandsymptomaticgeneralizedtonic-clonicseizure(GTCS),and36%forgeneralizedseizure(GS).Adecreaseinseizurefrequencyof50%andmorewasobtainedby41%ofpatientsforalseizuretypes,61%withGTCSand60%withGS.ItseemsthatLTGismosteficaciousinGS.Fifty-onepatientselectedtocontinuewithLTGfor4to15monchs(mean9months)hadasimilaref-fectsonseizurefrequencyascomparedwith3-monthfolow-up.Ninepatients(14%)becameseizure-free.FivechildrenwithLennox-Gastautsyndrome(LGS),3hadatleast96%seizurereduc-tionafterone-monthtreatment.Inaddition,areductioninproportionofpatientswithsevereandmedianabnormalEEGfrom50%to17%wasalsonotedafterLTGadministrationcomparedpre-LTGperiod.LTGwasweltolerated.Themostimportantadverseeventreportedbyourpatientswasalergicskinrashes,whichweregeneralymildanddisappearedwhenthetreatmentwasdiscon-tinued.
出处
《中华神经科杂志》
CAS
CSCD
1996年第1期33-37,共5页
Chinese Journal of Neurology
关键词
癫痫
抗癫痫剂
拉莫三嗪
EpilepsyAntiepilepticdrugsLamotrigine
