摘要
目的:探讨白塞病(BD)的临床特点。方法:回顾性分析42例BD患者的临床及实验室资料。结果:BD好发于青壮年,多慢性起病,可累及多个器官系统,各受累部位的频率依次为:口腔42例(100%),生殖器29例(69.0%),皮肤28例(66.7%),关节18例(42.9%),眼18例(42.9%),神经系统6例(14.3%),消化道4例(9.5%),大血管3例(7.1%),呼吸系统2例(4.8%),肾脏1例(2.4%),心脏1例(2.4%)。针刺反应阳性32例(76.2%)。皮肤组织活检12例,病理改变均符合皮肤血管炎。随访发现5例死亡个案中2例为BD肠病,1例为BD肺病,1例为BD脑病。结论:BD是一种以血管炎为基础的可累积全身多器官系统的免疫性疾病,重要脏器受累预后不良。皮质类固醇激素或联合应用免疫抑制剂有较好的临床疗效,但亦带来一定的副作用。
Objective：To investigate on the clinical characteristics and laboratory findings in patiets with Behcet＇s disease（BD）. Methods： Retrospectively evaluated the clinical and laboratory data of 42 patients with BD. Results： Most cases in this group were middle - aged individuals with chronic onset. The prevalence of mucocutaneous lesions and systemic manifestations were as following ：100% oral ulcer, 69% genital ulcer, 66.7% cutaneous lesions, 42. 9% articular involvement and 42.9% ocular involvement, 14.3% neurologic involvement, 9.5% gastrointestinal involvement, 7. 1% vascular involvement, 4.8% pulmonary involvement, 2.4% renal involvement and 2.4% cardiovascular involvement. 76. 2% of those cases were showed positive pathergy test . Histopathological finding revealed vasculitis. The follow -up showed that 2 patients died of gastrointestinal involvement, while another 2 cases died of pulmonary involvement and neurologic invovement respectively. Conclusion： Behcet＇ s disease is a disorder involved multisystem in which vasculitis is underlying histopathologic changes. Patients with vital organ involvements had a worse prognosis. Steroids combined with immunosuppressive agent were showed the good response, however some side -effects have to be monitored.
出处
《岭南皮肤性病科杂志》
2005年第3期199-201,204,共4页
Southern China Journal of Dermato-Venereology
关键词
白寒病
病例分析
Behcet＇s disease
clinical study
