摘要
目的为了研究白介素-2受体(IL-2R)、白介素-6(IL-6)、肿瘤坏死因子-α(TNF-α)在急性胰腺炎(AP)发病机制中作用及其临床应用价值。方法检测了68例急性胰腺炎患者急性发作期和临床缓解期血清中IL-2R、IL-6、TNF-α水平,并以50例正常健康人血清IL-2R、IL-6、TNF-α水平作为对照。结果68例AP患者急性发作期血清中IL-2R、IL-6、TNF-α水平显著高于正常对照组(P<0.01),而缓解期血清中IL-2R、IL-6、TNF-α水平与正常对照组相比仍然有差异(P<0.05)。结论血清IL-2R、IL-6、TNF-α在AP发病机制中发挥着重要的作用,同时也可作为病情变化的检测指标。
Objective To investigate the immunopathogenic changes of IL - 2R, IL - 6 and TNF - α and their clinical signiticance in patients with acute pancreatitis （AP）. Methods Sixty- eight patients with AP were evaluated the serum levels of these cytokins..Serum IL - 2R, IL - 6 and TNF - α were detected by ELISA in 68 patients with AP and 50 controls. Results IL- 2R, IL- 6 and TNF -α levels were increased in patients with AP. The data showed the levels of IL- 2R, IL- 6 and TNF- α levels were remarkable increased than those of the normal controls of AP （ P 〈 0.01）. But with the remission of the disease, IL - 2R, IL - 6 and TNF - α were decreased. Conclusion IL - 2R, IL - 6 and TNF - α might play a role in the development of AP. Decting serum IL- 2R, IL - 6 and TNF - α levels is of value to predicting the prognosis and determining the discontinuance of therapy in AP. The measurement of serum IL- 2R, IL - 6 and TNF- α levels is beneficial in the determing of higher value in the evaluation of treatment effect in AP.
出处
《医师进修杂志》
2005年第9期27-28,共2页
Journal of Postgraduates of Medicine
