摘要
目的比较中国健康汉族人和维吾尔族人GSTM1、GSTT1和GSTP1基因多态性分布。方法用多重PCR分析GSTM1和GSTT1基因多态性,PCR-RFLP检测GSTP15号外显子105位密码子基因多态性。结果汉族人与维吾尔族人的GSTM1纯合缺失频率接近,分别为56.1%和53.2%。而汉族人的GSTT1纯合缺失频率(50.0%)较维吾尔族人(26.6%)高。汉族人GSTP1105I/I、I/V和V/V基因型频率分别为60.7%,35.2%和4.1%;维吾尔族人分别为51.3%,40.2%and8.4%。结论维吾尔族人与汉族人,除GSTM1外,GSTT1与GSTP1突变基因型频率存在明显种族差异。
Objective To compare the frequencies of polymorphisms of GSTM 1, GSTF1, and GSTP1 in Chinese Uygur with those in Chinese Han. Methods GSTM1 and GSTF1 polymorphisms were analyzed by a polymerase chain reaction（PCR） -multiplex procedure, whereas GSTP1 polymorphism was analyzed by PCR - restriction fragment length polymorphism. Results The frequency of GSTM1 null genotype was 56. 1% in Chinese Han and 53.2% in Chinese Uygur, respectively. Whilst the frequency of GSTF1 null genotype in Chinese Han （50.0%） was higher than that of Chinese Uygur （26.6 % ）. The genotype distribution of GSTP1 was 60.7% I/I, 35.2% I/V and 4.1% V/V in Chinese Han and 51.3% I/I, 40.2% I/V and 8. 4% V/V in Chinese Uygur, respectively. Conclusion There is marked ethnic difference in the mutant frequencies of GSTF1 and GSTP1, but not GSTM1, between Chinese Uygur and Chinese Han.
出处
《中国临床药理学杂志》
CAS
CSCD
北大核心
2005年第4期264-267,共4页
The Chinese Journal of Clinical Pharmacology
