摘要
真骨鱼重链IgM恒定区基因由CH1～CH44个外显子所编码,以IgM分泌型表达,其跨膜域由2个外显子所编码,它以淋巴细胞膜受体形式被利用,TM1外显子被直接剪接到CH3外显子,而不是在CH4外显子内,这种不寻常的剪接方式导致产生Cμ4区的膜IgM。真骨鱼IgD重链除包括分泌型或膜结合型的C末端外,这个重组分子还包括1个重组的可变区、μ链的第1个恒定区及7个恒定区。IgD(δ)重链基因恰好位于IgM(μ)基因下游,第1个恒定区μ外显子被剪切形成δ转录本。
The immunoglobulin（IgM） heavy chain constant region gene of teleost fish contained four constant region domain-encoding exon（CH1 to CH4） expressed in secreted form of the immunoglobulin, and two exons encoding the transmembrane （TM） domain utilized in the lymphocyte membrane receptor form of the immunoglobulin. TM1 exon was spliced directly to the CH3 exon, and not into a site within the CH4 exon. This unusual pattern of splicing, which produced a membrane heavy chain that lacked the Cmμ4 domain. In addition to alternative secretory or membrane -associated C termini, the heavy chain of IgD which was a novel complex chimeric molecule contained a rearranged variable domain, the first constant domain of mμ and seven constant domains encoded by deta gene homolog. The IgD heavy chain （delta） gene was downstream of the IgM heavy chain （mμ） gene, the first constant mμ exon was spliced into the delta transcripts.
出处
《安徽农业科学》
CAS
北大核心
2005年第8期1484-1485,共2页
Journal of Anhui Agricultural Sciences
关键词
真骨鱼
IGM
IGD
遗传控制
Teleost fish
Immunoglobulin M
Immunoglobulin D
Genetic control
