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心肌细胞内皮素的信号传导 被引量：1

Endothelin Signaling in Cardiac Myocyte
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摘要 内皮素通过多种心肌细胞内信号途径调节心肌细胞的收缩特性,刺激心肌细胞生长和肌原纤维的产生、抗凋亡等作用。本文简要介绍心肌细胞内皮素激活蛋白激酶C、丝裂原激活蛋白激酶、磷酸肌醇3'羟基激酶/蛋白激酶B等信号通路的调节作用。 Endothelin can affect the growth and myofibrillogenesis, and increase contractile properties of cardiacmyocyte, stimulate myocyte resistance to apoptosis by intracellular signaling pathways. This article briefly reviews the regulative effects of these signaling pathways C, mitogen activated protein kinase, and phosphoinositide 3＇-OH kinase/protein including protein kinase kinase B.
作者 任安经 袁文俊
机构地区 第二军医大学生理教研室
出处 《中国医学科学院学报》 CAS CSCD 北大核心 2005年第4期529-533,共5页 Acta Academiae Medicinae Sinicae
基金 国家重点基础研究发展规划项目(973)基金(G2000056905)~~
关键词 心肌细胞:内皮素 信号传导 蛋白激酶C 丝裂原激活蛋白激酶 离子运动 cardiac myocyte endothelin signaling protein kinase C mitogen activated protein kinases ion movements
分类号 R331.36 [医药卫生—人体生理学]
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参考文献30

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二级参考文献32

共引文献17

同被引文献16

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中国医学科学院学报
2005年 第4期

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