摘要
目的研究胃癌患者血清血管内皮生长因子(VEGF)和一氧化氮(NO)水平的变化及其意义。方法采用酶联免疫吸附测定(ELISA)法与分光光度法分别检测VEGF和NO在胃癌、慢性胃炎患者以及健康人血清中的水平,并分析它们与胃癌临床病理因素的关系。结果胃癌患者血清VEGF和NO水平明显高于慢性胃炎患者以及健康人(均P<0.01);胃癌患者血清VEGF和NO水平之间具有相关性,VEGF和NO水平高低与胃癌的浆膜浸润、淋巴结转移和TNM分期有关。结论VEGF和NO在胃癌患者血清中明显升高,并与胃癌的病情进展、淋巴结转移相关。
Objective To study the serum vascular endothelial growth factor （VEGF） and nitric oxide （NO） levels in patients with gastric cancer and to elucidate their clinical significance. Methods Serum VEGF level was measured by enzyme linked immunosorbent assay （ELISA） and serum NO level detected by spectrophotometry in 65 gastric cancer patients, 50 chronic gastritis patients and 40 healthy individuals. Relationship between serum level of VEGF and NO and the clinicopathology of gastric cancer were discussed. Results The serum VEGF and NO levels in gastric cancer patients were significantly higher than those in patients with chronic gastritis and those of normal persons （P〈0.01）. Serum VEGF and No level correlated positively with tumor invasion depth, lymph node metastasis and TNM stage. Conclusion Level of serum VEGF and NO were elevated and related to the aggravation and lymph node metastasis in patients with gastric cancer.
出处
《浙江医学》
CAS
2005年第9期652-653,共2页
Zhejiang Medical Journal
