摘要
目的:观察依替膦酸钠对伴骨质疏松症的椎动脉型颈椎病的临床疗效。方法:将127例患者随机分为实验组(n=66)和对照组(n=61),两组分别给予依替膦酸钠和阿法D3治疗,并用双能X线骨密度测量仪及经颅多普勒测量患者的骨密度和椎动脉、基底动脉血流速度。结果:两组治疗后患者的症状积分均较治疗前明显下降(P<0.01),且以治疗组更为明显(P<0.01)。治疗6个月后,治疗组的疗效明显优于对照组(Hc=12.295,P<0.01)。治疗后,治疗组的骨密度、颈椎矢状径、椎-基底动脉血流速度均有明显升高(P<0.01),对照组除C4椎体密度无明显变化外,余指标均有明显上升(P<0.05或0.01),但以治疗组升高更为显著(P<0.05或0.01)。结论:依替膦酸钠对伴骨质疏松症的椎动脉型颈椎病有一定的疗效,双能X线骨密度测量仪和经颅多普勒对该病的疗效判定有重要意义。
Objective： To observe the efficacy of etidronate in the vertebral artery type of cervical spondylopathy （VACS） with osteoporosis （OP）. Methods： A total of 127 cases of VACS with OP were randomly divided into 2 groups; treatment group （n=66） received etidronate, and control group （n= 61） accepted α-D3. Their bone mineral density （BMD） and blood flow rate （BFR） of vertebral artery and basilar artery were detected by double energy X-ray bone density absorplimetry （DEXA） and transcranial doppler （TCD）. respectively. Results： Symptoms. BMD and BFR improved significantly after therapy in two groups （P〈0. 01）. especially in treatment group （P〈0.01 or 0. 05）. Conclusion： Etidronate is effective in the treatment of VACS with OP. and DEXA and TCD are helpful in evaluating the therapeutic efficacy.
出处
《广东医学院学报》
2005年第5期507-509,共3页
Journal of Guangdong Medical College
