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肺动脉高压小儿体外循环后氨力农的临床应用

Clinical Studies on Amrinone Using in Children with Serious Pulmonary Hypertention after Extracoreal Circulation
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摘要 目的探讨氨力农在小儿重度肺动脉高压心内直视术后的临床应用价值.方法选择术中应用氨力农的重度肺高压心内直视术病儿45例,年龄(3.9±0.8)岁,体重(10.6±3.2)kg,用药时间为(67.2±9.7)h,剂量5~10μg·kg-1·min-1,观察用药前、后血流动力学的变化.结果应用氨力农后临床症状明显改善,平均肺动脉压用药后2~5h明显下降(P<0.01)且不增加心肌耗氧量.结论氨力农对改善小儿重度肺高压心内直视术后心功能,降低肺动脉压,临床效果显著. Objective To evaluate the clinical value of amrinone after open heart surgery in the children with serious pulmonary hypertension (PH). Methods Forty-five children with serious PH after open heart surgery were treated by amrinone ( AR), with the age of ( 3.9 ± 0.8 ) years, and weight ( 10.6 ± 3.2 ) kg, the mean time of medication ( 67.2 ± 9.7 ) hour, and the dosage 5 ~ 10μg· kg^-1 ·min^-1. The hemodynamics changes before and after the administration of AR were observed. Results The clinical symptoms were obviously improved. The mean pulmonary artierial pressure was decreased 2 ~ 5 bours after the use of AR without inereasing the myoeardium oxygen consumption. Conclusion AR is more effective to improve cardiac function and reduce puhnonary arterial pressure in children with serious PH after open heart surgery.
出处 《潍坊医学院学报》 2005年第4期260-261,共2页 Acta Academiae Medicinae Weifang
关键词 氨力农 肺动脉高压 小儿 体外循环 Amrinone Pulmonary hypertension Extracoreal circulation
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  • 1M. Berner,M. Beghetti,B. Ricou,J. C. Rouge,R. Prêtre,B. Friedli. Relief of severe pulmonary hypertension after closure of a large ventricular septal defect using low dose inhaled nitric oxide[J] 1993,Intensive Care Medicine(2):75~77 被引量:1

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