摘要
目的探讨急性肺血栓栓塞症(PTE)患者溶栓治疗前后血小板活化及内皮功能的变化及临床意义。方法采用全血流式细胞术测定36例急性PTE患者和20例健康对照者血小板膜糖蛋白CD62p、CD41/CD61,用酶联免疫吸附测定(ELISA)法测定血浆血管性假血友病因子(vWF),并比较PTE患者溶栓治疗前后各项指标的变化。结果PTE患者CD62p、CD41/CD61、vWF分别为(12.07±6.54)%、(18.3±12.2)%、(194.1±22.3)%,显著高于对照组(P<0.01);治疗1周后各项指标较前明显下降,分别为(4.48±3.30)%、(6.6±4.0)%(、116.3±28.0)%(均P<0.01)。结论急性PTE患者存在血小板活性增强和内皮功能异常,这些变化与PTE的病理过程有关。
Objective To investigate the changes and clinical significance of platelet activation and endothelial cell disturbance in the pathogenesis of acute pulmonary thromboembolism（PTE）. Methods Platelet activation factor CD62p,CD41/CD61 were detected by flow cytometry,and the plasma von Willebrand factor（vWF） was measured by enzyme linked immunoadsorbent assay （ELISA） in 36 patients with acute PTE and 20 normal subjects,and the changes of these factors were compared between before treatment and one week later. Results In PTE group, the levels of platelet activation factor CD62p,CD41/CD61, vWF were significantly higher than those in control group, respectively （12.07±6.54） %,（18.3±12.2） % and （194. 1±22.3） %（P 〈0.01）. After one week of treatment the levels of these factors were significantly lower than those before,respectively（4.48±3.30） %,（6.6±4.0） %,（116. 3±28. 0） （ P 〈0.01）. Conclusion Patients with acute PTE show evidence of enhanced platelet activation and endothelial cell disturbance,which relates to pathological process of PTE.
出处
《临床荟萃》
CAS
北大核心
2005年第17期971-973,共3页
Clinical Focus
关键词
肺栓塞
血小板活化
血小板膜糖蛋白类
内皮功能
pulmonary embolism
platelet activation
platelet membrane glycoproteins
endothelial cell function
