摘要
目的:通过对PCI术前、术后IL—10、IL—18浓度的变化与心血管不良事件的相关性的研究,探讨PCI术后心血管不良事件发生的机制,以及与IL—10、IL—18的相关性。方法:观察70例PCI患者术前及术后4h血清IL—10、IL—18变化。并随访术后12个月内的心血管事件,比较术前、术后以及发生不良心血管事件组与未发生组之间血清IL—10和IL—18变化的差异。结果:冠脉造影组术前术后的IL—10、IL—18的浓度均低于PTCA组,差异有显著性(P<0.05)。PCI后12hIL-18、IL—10水平显著高于术前(P<0.01)。发生不良心血管事件的患者术后血清IL—18升高的幅度明显高于未发生组(P<0.01),IL—10升高的幅度则明显低于未发生组(P<0.05)。结论:①PCI后存在炎性反应,IL—10、IL—18是反映PCI后早期炎性反应的敏感指标;②其变化程度与不良心血管事件的发生可能存在相关性,即IL—10可能与不良心血管事件的发生呈负相关,IL—18可能与不良心血管事件的发生呈正相关;③IL—10、IL—18变化的幅度可能作为PCI术后发生不良心血管事件的预测指标。
Objective： To investigate the changes of serum interleukin - 10 and interleukin - 18 before and after percutaneous coronary intervention（PCI） therapy and their correlation with cardiovascular events, for exploring the mechanism of cardiovascular events after PCI and its correlation with IL- 10 and IL- 18. Methods： In 70 patients performed PCI,the levels of IL- 10 and IL- 18 were detected before and 4 hours after therapy, the cardiovascular events were followed up 12 months after therapy. The levels of IL- 10 and IL - 18 before and after therapy were compared between group with cardiovascular events and group without cardiovascular events. Results：The concentrations of IL- 10 and IL- 18 in PCI group were lower than that in PICA group, the difference was significant（P〈0.05）. The levels of IL- 18 and IL- 10 were significantly higher 12 hours after PCI than that before PCI （P〈 0.01 ）. ComparedWith patients without cardiovascular events, the degree of increasing IL- 18 was significantly higher and that of increasing IL- 10 was lower in patients with cardiovascular events （ P 〈 0.01, P 〈 0.05）. Conclusion ： There is inflammation after PCI. I L - 10 and IL - 18 are sensitive to reflect early inflammation after PCI. There is correlation between tile changes of IL- 10 and IL - 18 and cardiovascular events. The changing degree of IL - 10 and IL- 18 may be one of predictors for cardiovascular events after PCI.
出处
《内蒙古医学杂志》
2005年第9期769-772,共4页
Inner Mongolia Medical Journal
